CRAB, in partnership with the Fred Hutchinson Cancer Research Center, is the Statistical Center for SWOG, one of the largest of the National Cancer Institute-supported cancer clinical trials cooperative groups. SWOG’s primary mission is to improve the practice of medicine in preventing, detecting and treating cancer. The mission is accomplished through the mutual efforts of the Group Chair’s Office in Ann Arbor, Michigan, the Operations Office in San Antonio, Texas, the Statistical Center in Seattle, Washington and the dedicated oncology professionals in the institutions of the Group.
As the Statistical Center, CRAB participates in the design, support, and analysis of trials to address important hypotheses in cancer treatment and prevention, and in the translation of biologic concepts to clinical care. Quality research, quality data, and the publication of results are critical to this effort. Approximately 100 clinical trials are underway at any given time. On average, 5,000 cancer patients and healthy participants are enrolled each year and 30,000 more are involved annually in ongoing clinical trials.
The Statistical Center at CRAB contributes through the following - click a subject below for information:
Study Design and Protocol Review
Biostatisticians participate in the development of proposed protocols, particularly in regards to experimental design, sample size and feasibility. Biostatisticians also perform statistical research on the efficient design, conduct and analysis of cancer clinical trials and cancer control research, with special emphasis on designs for translational studies.
Biostatisticians and Data Coordinators provide independent internal review of study protocols with respect to the appropriateness of the design and data collection for the scientific aims, for consistency with general guidelines, and for clarity of eligibility and other study requirements.
Information Technology and Software Development
The Statistical Center evaluates, develops and maintains state-of-the-art information technology to support its objectives. The Information Technology staff provides and sustains hardware support for computer processing and storage of data.
Our Application Developers are responsible for creating and supporting many custom software applications used by the institution membership, as well as internal staff at the Statistical Center, Group Chair’s Office, and Operations Office. Staff also evaluate and utilize commercial software products as applicable. We are adapting our systems to the Medidata Rave data capture systems all cooperative groups are mandated to deploy. All of our applications support the research and goals of SWOG, including data collection, data management, data retrieval and analysis.
Data Quality Control, Monitoring, Analysis and Publication
The Statistical Center collects, reviews, manages and stores data from all active SWOG studies, and follows quality control and review procedures which ensure the integrity of the data evaluation. Data managers and statisticians collaborate with sites to make sure study data is complete, accurate and available for analysis in real time.
The Statistical Center is responsible for statistical analysis and interpretation of all SWOG studies. Biostatisticians analyze and publish the results of studies in conjunction with the Study Coordinators (principal investigators).
Innovation and Education
SWOG is a world leader not only in the quality of its research but in innovations in the conduct of clinical trials. This knowledge is shared with group member and collaborators beyond our borders.
The Statistical Center has an active, basic statistical research program addressing ongoing design and analysis issues important to the conduct of cancer clinical trials and to ancillary biologic studies.
Communications and Collaboration
Statistical Center staff work with the Group Chair and other investigators in the Group to improve the quality of clinical trials through the use of improved data collection forms, reproducible data definitions and economical data flow, and efficient use of Statistical Center resources.
Training and Education
The Statistical Center plays a key role in the training of new Clinical Research Associates (CRAs) and of Young Investigators in the Group, and to collaborators in Asia and Latin America. Biostatisticians and Data Coordinators educate investigators, nurse oncologists and Clinical Research Associates in statistical analysis, research design and the utilization of the most advanced scientific and data management strategies.