News & Events Archive

CRAB Co-Founder Honored for Influential Research

CRAB Co-Founder John Crowley, PhD, has once again been recognized as most-influential in the field of clinical medicine. Clarivate Analytics has listed Dr. Crowley as one of its Highly Cited Researchers for 2016. This is the second year in which Dr. Crowley has garnered this distinction, which is given to researchers that have a global impact in their respective fields through their published works. Dr. Crowley and the other honored researchers for 2016 are listed on the award’s official website.

Dr. Crowley is the author of more than 400 peer-reviewed professional papers, and has contributed to and edited several books on the methodology of clinical trials, including Handbook of Statistics in Clinical Oncology, Third Edition and Clinical Trials in Oncology, Third Edition. Dr. Crowley’s affiliation with the University of Washington is highlighted with the Clarivate honor. The University thanked Dr. Crowley in their congratulatory letter to him, for his “incredible contributions to the clinical medicine community.”


Doug Mounce Published and Honored by the SRAI

Judicial interpretation of Food and Drug Administration regulations on clinical trial sponsorship in cases of injury claims is the focus of a paper co-authored by Doug Mounce, CRAB’s Grants and Contracts Manager, Frank X. Curci, partner at Ater Wynne, LLP, and a member of the CRAB Board of Directors, and Joshua B. Fortenbery, intern at Ater Wynne. The paper, Spotlight on Clinical Trial Sponsorship, was published by the Society of Research Administrators International (SRAI) in the Spring 2016 issue of their Journal of Research Administration. The authors’ goal for the article was to provide some guidance as to what liability is currently associated with assuming the role of “sponsor” in a clinical trial.

Mr. Mounce was also awarded a scholarship to attend the Society of Research Administrators International (SRAI) conference held Oct. 22-26 in San Antonio where he presented a session on clinical trial sponsorship, and a poster based on the paper. We congratulate him for these achievements.


Did you miss #GivingTuesday?
You can still support CRAB!


CRAB proudly participated in the movement of generosity that is #GivingTuesday, supporting our favorite causes and charities through online giving and social media collaboration. Support for these charities, and for CRAB, is still needed, and you can still help!

CRAB is focused on people, people you may know in local, national, and global communities - people with underfunded and under-researched cancers, the ones we can’t yet cure, such as myeloma, pancreatic and lung cancers. Together, we can help these people. CRAB helps bring new choices to patients - one of these could be the one that makes a difference. With your contributions, we can build upon CRAB’s successes to provide more treatment options to even more cancer patients, sooner.

You can donate to CRAB’s work, via credit/debit card or PayPal, by clicking this link: https://www.razoo.com/us/story/Cancer-Research-And-Biostatistics.

Thank you for supporting CRAB!


CRAB Executive Attends State Governor’s Life Sciences Summit

SEATTLE, October 28, 2016 – Tammy Buist, VP and Chief Business Development Officer, represented Cancer Research And Biostatistics (CRAB) at a Life Science Washington event, the 12th Annual Governor’s Life Sciences Summit & Annual Meeting. Ms. Buist stated that this was “an exciting event with great attendance showing a commitment to the Life Sciences sector in Washington State”.

The summit was sponsored by a host of life science organizations from across Washington, and featured presentations on life science industry trends, a talk and question-and-answer session with Governor Jay Inslee, and a panel discussion with state legislators on how Washington might help local life sciences companies flourish and innovate. The history and future of drug development and cancer care was discussed, with cell-based therapies and immunotherapy highlighted as a positive and profound shift in cancer therapy.

Washington Governor Jay Inslee speaking at the 2016 Governor’s Life Sciences Summit. (GeekWire Photo / Clare McGrane)

Washington Governor Jay Inslee speaking at the 2016 Governor’s Life Sciences Summit. (GeekWire Photo / Clare McGrane)


CRAB CEO a Panelist in Remote Collaboration Discussion

CRAB partnership with Oregon Health & Science University (OHSU) was represented at a panel discussion on remote-collaboration this summer. CRAB President and CEO, Antje Hoering, PhD, served as a panelist for an invited talk titled “Extraordinary Power of Remote Collaboration and Team Science.” The event was the Joint Statistical Meeting (JSM) in Chicago, held in August.

Topics of the discussion included critical factors of successful collaboration (building trust, shared vision and recognition, conflict resolution) and exploration of what makes remote, multi-disciplined scientific research teams healthy and productive. Antje Hoering from CRAB, and Motomo Mori, director of the Biostatistics Shared Resource at the OHSU Knight Cancer Institute, were selected as panelists due to their success in remote-team collaboration; they helped describe how statisticians can be effective leaders and facilitators for such teams.

 




CRAB CEO a Panelist in Blood Cancer Clinical Trials Discussion

Innovation in medicine and addressing unmet medical needs in the face of life-threatening illnesses were elements of a public meeting that CRAB attended this year. CRAB President and CEO, Antje Hoering, PhD, served as a panelist in the discussion titled “Minimal Residual Disease as a Surrogate Endpoint in Hematologic Cancer Trials.” The day-long meeting was held in Washington, DC in September. The chief topic was the use of minimal residual disease (MRD) as a surrogate endpoint in clinical trials for blood cancers.​

The discussion covered the regulatory background, statistical basis and evidence to support the use of MRD as a surrogate endpoint in clinical trials for new treatments of acute myeloid leukemia, acute lymphocytic leukemia, chronic lymphocytic leukemia, and multiple myeloma. Dr. Hoering spoke as a statistician on the myeloma panel at the event.


CRAB Strode with PurpleStride Puget Sound 2016

On Sunday, October 30, 2016, employees, colleagues, family and friends of Cancer Research And Biostatistics (CRAB) united for the fourth consecutive year to support awareness and research for pancreatic cancer. CRABCares, the CRAB public-outreach committee, participated in the 2016 PurpleStride Puget Sound event at Magnuson Park in Seattle. CRAB staff, along with friends and family members, showed support for the larger Seattle community of survivors, researchers and awareness activists as they strode in this 5K fun-run/walk, to share stories, smiles and conversation.​

Each year, in communities across the US, tens of thousands of people participate in more than 56 PurpleStride events. These events are critical in raising awareness and funds that advance research and support patients and loved ones with a promise of a better tomorrow. One of CRAB's key research partnerships, the Pancreatic Cancer Research Team (PCRT), has member-sites across the US that participate in PurpleStride events throughout each year.

John Crowley, co-Founder and Chief of Strategic Alliances at CRAB, pledged to support PurpleStride Puget Sound this year: "CRAB is proud to stride with PanCAN in support of our shared mission to help conquer pancreatic cancer. This effort is very important to me, personally and professionally. Therefore, I have pledged to match every dollar raised by the CRABCares team for PanCAN through this event with a dollar to CRAB in support of the PCRT."


Support CRAB on #GivingTuesday


We’ve shared feasts and good company for Thanksgiving and retail deals on Black Friday and Cyber Monday. We also have a day to share our support for our favorite causes and charities, to nurture our communities - #GivingTuesday, a day of online giving, powered by social media and collaboration. Cancer Research And Biostatistics (CRAB) is proud to participate in this movement of generosity again, on November 29, 2016.

CRAB is focused on people, people you may know in local, national, and global communities - people with underfunded and under-researched cancers, the ones we can’t yet cure, such as myeloma, pancreatic and lung cancers. Together, we can help these people. CRAB helps bring new choices to patients - one of these could be the one that makes a difference. With your contributions, we can build upon CRAB’s successes to provide more treatment options to even more cancer patients, sooner.

In advance of #GivingTuesday, you can include the hashtag #GivingTuesday to spread the word about the movement and causes you care about. On #GivingTuesday, you can donate to CRAB’s work, via credit/debit card or PayPal, by clicking this link: https://www.razoo.com/us/story/Cancer-Research-And-Biostatistics.

Thank you for supporting CRAB on #GivingTuesday!


CRAB Treads with PurpleStride Puget Sound 2016

On Sunday, October 30, 2016, employees, colleagues, family and friends of Cancer Research And Biostatistics (CRAB) unite for the fourth consecutive year to support awareness and research for pancreatic cancer. CRABCares, the CRAB public-outreach committee, will participate in the 2016 PurpleStride Puget Sound event at Magnuson Park in Seattle. CRAB staff, along with friends and family members, will show support for the larger Seattle community of survivors, researchers and awareness activists as they stride in this 5K fun-run/walk, to share stories, smiles and conversation.​

Each year, in communities across the US, tens of thousands of people participate in more than 56 PurpleStride events. These events are critical in raising awareness and funds that advance research and support patients and loved ones with a promise of a better tomorrow. One of CRAB's key research partnerships, the Pancreatic Cancer Research Team (PCRT), has member-sites across the US that participate in PurpleStride events throughout each year.

John Crowley, co-Founder and Chief of Strategic Alliances at CRAB, has pledged to support PurpleStride Puget Sound this year: "CRAB is proud to stride with PanCAN in support of our shared mission to help conquer pancreatic cancer. This effort is very important to me, personally and professionally. Therefore, I have pledged to match every dollar raised by the CRABCares team for PanCAN through this event with a dollar to CRAB in support of the PCRT."

We encourage you to join us. You can visit the CRABCares team site to register, make a donation or to learn more about PurpleStride Puget Sound - http://support.pancan.org/site/TR/PurpleStride/PurpleStride?team_id=2140&pg=team&fr_id=1151.


CRAB Host to the Young Investigators, September 26-28, 2016

The annual SWOG Young Investigators conference was hosted by CRAB September 26th through ​28th. The conference featured SWOG leadership members, CRAB data managers and six investigators who were introduced to SWOG protocol development, maintenance, and administration. We say thank you to this year's group:​

Uma M. Borate, MD, MS
Virginia Sun, RN, PhD
Erin F. Cobain, MD
Cecilia C.S. Yeung, MD
Kristen M. O'Dwyer, MD
Emma C. Scott, MD


CRAB Mourns Loss of Valued Friend and Supporter

It is with great sadness that we inform you of the passing of longtime CRAB friend – Roy Powell, on August 9.

An accomplished artist and custom home builder, Roy Powell left beauty behind in the form of his free standing steel sculptures, original furniture design, ceramics and homes.

His work can be seen throughout Washington, Oregon and the Sacramento, CA areas. A native of Southern California, Roy attended the University of Redlands and received a master’s degree in teaching from nearby Chico State College. Prior to embarking on a home building and renovating career, Roy was a valued high school educator in the Madeira, CA area for nine years.

Roy was diagnosed with glioblastoma in early 2015 and underwent two surgeries and chemotherapy and radiation therapy to remove the brain tumors. After his year and a half fight against this aggressive cancer, Roy died peacefully in his sleep on August 9.

His passing is an incredible loss and he is greatly mourned by his numerous friends, family and all who knew him. Roy is survived by his wife, Ruth Crowley, and brother-in-law and CRAB co-founder, John Crowley.

The work of cancer research and awareness, specifically, Cancer Research And Biostatistics (CRAB), was of great importance to Roy. In his passing, his family has requested that donations be made to the Seattle-based non-profit organization. Anyone wishing to make a donation in Roy’s name may send their contribution to Cancer Research And Biostatistics (CRAB), at 1730 Minor Avenue, Suite 1900, Seattle WA 98101. Donations are also accepted online via CRAB.org/donate.

CRAB extends its heartfelt condolences to Roy Powell’s family at this time along with our deepest appreciation for his support of our work.


John Crowley Inducted as a Fellow of the Society for Clinical Trials

John Crowley, PhD, has been inducted as a Fellow of the Society for Clinical Trials (SCT), a scientific organization that advocates for the use of optimal methods and practices in clinical trials. Dr. Crowley, CRAB’s co-founder and Chief of Strategic Alliances, received the honor in May during the SCT’s 37th Annual Meeting in Montreal.

The SCT inducted Dr. Crowley for his “…important contributions to survival analysis and to the statistical methodology for the design and analysis of cancer clinical trials; for leadership in clinical trial coordination and conduct through SWOG, a national cancer clinical trials consortium; for key roles in clinical trials that advanced outcomes for patients with myeloma, lung cancer and pancreatic cancer; and for contributions to the education and training of clinicians and statisticians in the methods of cancer clinical trials.”

Created in 1978, the SCT is an international professional organization dedicated to the development and dissemination of knowledge about the design, conduct, and analysis of government and industry-sponsored clinical trials and related health care research methodologies. The Society established the title of “Fellow of the Society for Clinical Trials” in 2005, to honor society members who have made significant contributions to the advancement of clinical trials and to the society. With the Fellow honor, Dr. Crowley joins a very distinguished international group of physicians, clinicians and researchers from many scientific disciplines.


CRAB's First Fully-Validated Registration Trial May Change Standard-of-Care for AML Patients

Cancer Research And Biostatistics (CRAB), a non-profit organization whose mission is to help conquer cancer through application of biostatistical principles and data management methods, reached a milestone in early 2016. CRAB successfully completed a fully-validated registration clinical trial with Celator Pharmaceuticals that yielded significant, positive results for patients with high-risk acute myeloid leukemia (AML). With this project, CRAB demonstrates its capacity and talent to run Phase III registration trials, which is a notable achievement for the organization.

Celator, whose mission is to extend and improve the lives of cancer patients through innovation in combination therapy, announced improvement in overall survival and induction response rate in the Phase III trial for VYXEOS™ (CPX-351) in patients with AML.

Patients with high-risk AML were randomized to receive current standard of care (7+3) or CPX-351 (cytarabine: daunorubicin, Liposome for Injection).  Patients in the CPX-351 arm had a significantly longer median overall survival time (9.56 months) compared to patients randomized to the standard therapy group (5.95 months) (HR=0.69, p=0.005).

With a 12-person team, CRAB provided electronic data capture, data management and statistical analysis for this Phase III clinical trial. CRAB’s team included biostatisticians, program and project managers, regulatory and quality assurance managers, data managers, application developers, and project specialists.

“This has been a true team effort and a steep learning curve for all of us at CRAB,” said CRAB CEO Antje Hoering, PhD. “It is most exciting for the AML patient for whom little progress in treatment has been made in many years. This study may change standard of care for these patients. It is also a real milestone for CRAB as this is our first registration trial with all its regulatory requirements.”

CRAB’s CEO recently accompanied the trial sponsor to Washington, DC for a pre-New Drug Application meeting for VYXEOS™ (CPX-351) to the Food and Drug Administration.

The results of this clinical trial are exciting developments for CRAB as it continues its mission to conquer cancer, and, most importantly, for AML patients for whom there has been limited progress in the development of treatments.

For more information about the VYXEOS™ (CPX-351) registration trial, please visit Celator’s press release via this link.


CRAB Presented at 2016 SRA International Western/Midwest Section Meeting

Doug Mounce, Grants & Contracts Manager, Tammy Buist, Chief Business Development Officer, and Frank X. Curci JD, Ater Wynne LLP, CRAB Board Member, presented at the 2016 Western/Midwest Section Meeting of the Society of Research Administrators (SRA International) at 9:00 AM on Wednesday, May 18, 2016 at the Portland Marriott Downtown Waterfront. The presentation title is W106: Spotlight on Clinical Trials.

There is a natural concern with the responsibility implied by assuming the role of “sponsor” in a clinical trial agreement. In addition, the investigator is the sponsor for Investigator Sponsored Trials (ISTs, sometimes called Investigator Initiated Trials or IITs - the type of trials that CRAB often manages for the Clinical Trials Consortium). This presentation gave an overview on (1) Navigating the Waters of Clinical Trials, (2) Rules and Regulations that Impact Institutional Policies and Procedures, and (3) Legal Considerations that Impact Clinical Trial Sponsorship. Slides from the presentation are available here: (PowerPoint)


SWOG Myeloma Trial Therapy Lengthens
Time Before Reoccurrence and Life

At the 57th annual meeting of ASH, the American Society of Hematology, on Dec. 5, 2015, SWOG presented exciting results from the S0777 clinical trial on myeloma that may indicate a new standard of care for this disease.

S0777 is a Phase III clinical trial in front-line Multiple Myeloma which enrolled 471 eligible and analyzable adult patients, ages 28 to 87, between February 2008 and February 2012 at institutions of the National Cancer Institute National Cancer Trials Network. Patients were randomized to two treatment groups. One group received standard first-line treatment of lenalidomide and dexamethasone while the other group received lenalidomide and dexamethasone combined with bortezomib, a drug that is typically given as a second-line therapy to patients whose cancer progresses. At ASH, SWOG researchers revealed that patients in the three drug arm that included bortezomib had a median remission time of 43 months compared to 30 months in the two drug arm and lived a median of 75 months compared to 64 months in the arm with only lenalidomide and dexamethasone.

CRAB contributed to this trial with statistical, data management, and technology support as a member of the SWOG Statistical and Data Management Center housed at the Fred Hutchinson Cancer Research Center and CRAB.

For more information on the results, please read SWOG’s press release here: http://swog.org/Visitors/Download/Media/S0777PressRelease.pdf.


CRAB Hosts Training Event in Clinical Trial Design

Cytel will host a one-day training seminar at CRAB on Monday, April 11, 2016 on the topic of Applying Advanced Methods in Clinical Trial Design. To register for this event and to learn more about it, please click the "Register Now" button below.


Cancer Will Be The No. 1 Killer In The US

Cancer is a major health problem and is currently the second leading cause of death in the United States. It is expected to surpass heart disease as the leading cause of death in the US soon. As the sobering statistics reveal, funding cancer research is more of a priority than ever. Access the statistics from the American Cancer Society here: http://bit.ly/1PPV2A0

 


Thank You For Your Support On #GivingTuesday

Great thanks to our donors and supporters for their generous contributions on #GivingTuesday. At CRAB the day was full of fun, support and celebration, including our Met Park East lobby social event. The even was well-attended by building neighbors and visitors alike. We raffled off two art-graphics t-shirts from BYDFAULT; congratulations to our winners, Julie Fox (pictured below) and Cynthia McRain! 

Missed #GivingTuesday? It's not too late to make your tax-deductible donation to CRAB. Donate today!

 

 


December 10 -13: Make a Difference with Art

 


CRAB Founder Gives Presentation at OHSU

On December 9th, our founder, John Crowley, Ph.D., will give an invited presentation at the Oregon Health Science and University (OHSU) titled "Some Thoughts on Informatics and Reproducible Cancer Research". The talk is open to the public and designed for an audience of basic and applied scientists, students and professionals in healthcare. The presentation will describe integration of basic science investigations with clinical care and the conduct of clinical trials. For on-site location information and more details about the event please visit the Knight Cancer Institute website (link).

 

 


 


Make Cancer Research a Priority on December 1

 


CRAB Has Arrived...

CRAB now has an official Facebook page, located at https://www.facebook.com/CRABResearch. This page has been created to help further CRAB's work to engage community on the web and raise visibility of our work in cancer research. We hope that you enjoy the page and we encourage you to like and share it. 

 


 

CRAB Founder Gave Keynote at Vanderbilt University

On October 13, 2015, CRAB's Chief of Strategic Alliances, John Crowley, PhD., gave an invited keynote talk at the Vanderbilt Center for Qualitative Sciences' 2015 CQS Fall Retreat for their faculty, staff and trainees. The audience for the talk was an interdisciplinary group of Vanderbilt scientists from fields with a quantitative focus, including biostatistics, bioinformatics, biomathematics, systems biology, computational biology, statistical genetics and epidemiology. The talk was conceived to foster familiarity and collaboration among these groups. 

Dr. Crowley's keynote talk was titled "Through The Looking Glass: Some Thoughts on Quantitative Science and Interdisciplinary Research".  Dr. Crowley noted that "this was a great opportunity to showcase CRAB's contributions to clinical and translational cancer research for a distinguished group of scientists." 






CRAB In-Step with Pancreatic Cancer Awareness

Employees, colleagues, family and friends of Cancer Research And Biostatistics (CRAB) joined together on Sunday, November 1, 2015 to support awareness and research for pancreatic cancer. CRABCares, the CRAB public-outreach committee, participated in the 2015 PurpleStride Puget Sound event at Magnuson Park in Seattle. CRABCares members strode in this 5K fun-run/walk, sharing stories, smiles and conversation with the larger community of survivors, researchers and awareness activists.

Each year, in communities across the US, tens of thousands of people participate in more than fifty-six PurpleStride events. These events are critical in raising awareness and funds that advance research and support patients and loved ones with a promise of a better tomorrow. One of CRAB's key research partnerships, the Pancreatic Cancer Research Team (PCRT), has member-sites across the US that participate in PurpleStride events throughout each year.

We hope you had a great time at the event!


CRAB’s Impact at International Association for the Study of Lung Cancer Research Conference

On September 5th, 2015, CRAB scientists attended the meeting of the IASLC Staging and Prognostic Factors Committee at the IASLC 16th World Conference on Lung Cancer. John Crowley, Lynn Shemanski, Kari Chansky, Alan Mitchell and Vanessa Bolejack represented CRAB at this event, where proposals for revising the staging systems for lung cancer and mesothelioma were reviewed.

The 8th revision of the staging system for lung cancer was later presented at the event’s plenary session. CRAB’s expertise was highlighted as a statistics and data center. The 8th revision of the staging system for mesothelioma was also presented. “It is very gratifying to see our work over the past seven years being presented to this international audience,” noted Dr. Crowley. If approved by the American Joint Committee on Cancer and the Union Internationale Contre le Cancer, the new staging systems will be implemented in January of 2017.

Also at the meeting, Suzanne Arnold, MD. of the University of Kentucky presented a poster describing the phase I results for the CRAB Lung Cancer Research Team trial 11-001, IASLC 241.




CRAB Hosts Young Investigators Conference

The annual SWOG Young Investigators conference was hosted by CRAB September 9th through 11th, 2015. The conference featured SWOG leadership members, CRAB data managers and six investigators who were introduced to the ways and means of SWOG protocol development, maintenance and administration.

For more details about the event please visit the SWOG website: 

https://swog.org/Visitors/InvestigatorsTraining.asp

 

CRAB Stages Important Cancer Biostatistics Conference

On August 14 and 15, the first Pacific Rim Cancer Biostatistics Conference took place at the historically-designated Washington Athletic Club (WAC) in Seattle, Washington.

With the generous support of our sponsors - the Institute of Statistical Mathematics (ISM) and Kakenhi (Japan Society for the Promotion of Science: Grants-in Aid for Scientific Research), we brought together well-renowned statisticians in oncology research to collectively share breakthroughs, foster innovation, and advance statistical methods to conquer cancer.

The two-day event was well attended by Statisticians, Professors of Biostatistics, and oncology research professionals with an international group of twenty highly-regarded speakers presenting on cutting edge sessions in the areas of clinical and translational research in oncology, prognostic analysis and risk prediction, predictive modeling and performance assessment, screening/epidemiology, and analysis of genomic/imaging data. The group even braved the rain and Seahawks game traffic to attend a post-conference dinner!

We thank our sponsors, presenters, partners and attendees for their partnership and participation and for helping to make the inaugural Pacific Rim Cancer Biostatistics Conference a tremendous success.












 

CRAB, Berg and BIDMC Align with PurpleStride Boston 2015

Berg Biosystems and Beth Israel Deaconess Medical Center (BIDMC) joined forces to fight pancreatic cancer at Purple Stride on Sunday, August 16, 2015 at Boston Common. BIDMC served as honorary chair of the Pancreatic Cancer Action Network (PanCAN) for the day. BIDMC set up a tent at Purple Stride Boston to represent its joint-mission with PanCAN, promote BIDMC clinical services, and build buzz around Project Survival in the community most affected by pancreatic cancer.

The event increased visibility of Project Survival, a multi-institutional collaboration targeted at pancreatic cancer to discover breakthrough diagnostics and allow for development of targeted treatments against pancreatic cancer. To learn more about Project Survival please visit this link: http://bit.ly/1GSJwA5. Niven Narain, CEO of Berg Biosystems, discusses Project Survival in this Fox Business Interview on YouTube: https://youtu.be/FhnTsgJK9W8.


 

 


CRAB Aligned with Lung Cancer Awareness Group

CRAB joined with the "Community of Hope" - aligning our mission to help fight and raise awareness of lung cancer. On Saturday, August 8th 2015, CRAB's outreach committee, CRABCares, participated in the Breathe Deep Seattle fun-run/walk at Seward Park. The event was hosted by Lungevity. CRABCares members, their families and their friends enjoyed conversation, coffee and interactions with the greater lung cancer survivorship community. Smiles and stories were shared by attendees.


CRAB and Berg Honor Cancer Survivors at Fenway Park

July 10, 2015 - Researchers from Cancer Research And Biostatistics (CRAB), Berg Biosystems and Beth Israel Deaconess Memorial Hospital recognized cancer survivors at a Red Sox vs Yankees game at Fenway Park. CRAB researchers John Crowley, PhD and Amy Stoll-D’Astice, Dr. Ramesh Ramanathan, MD along with Dr. Jim Moser, MD from BIDMC and Niven Narain, CEO of Berg, gathered in Boston for a weekend meeting at Berg’s offices to discuss Project Survival, Berg’s multi-institutional initiative in pancreatic cancer targeted therapies. Amy Stoll-D'Astice called the Fenway Park event "a wonderful recognition of Pancreatic Cancer survivors with a team hoping to “hit it out of the ballpark” with Project Survival". Read more about Project Survival at this link: http://bit.ly/1GSJwA5.


Pancreatic Cancer Biomarker the Goal of “Project Survival”

SEATTLE, June 18, 2015 – Cancer Research And Biostatistics (CRAB) is working through our Pancreatic Cancer Research Team (PCRT) network on "Project Survival," a multi-institutional collaboration targeted at pancreatic cancer to discover breakthrough diagnostics and allow for development of targeted treatments against pancreatic cancer. CRAB and the PCRT network provide the essential infrastructure and expertise for a project with these lofty goals. You can view an interview with Niven Narain, CEO of Berg, with Diedre Bolton of Fox Business on her Risk & Reward show at this link: https://youtu.be/FhnTsgJK9W8.

More information about the project can be found here: http://bit.ly/1GSJwA5.

If you are interested in supporting cancer research please consider a donation to CRAB, a 5013c non-profit research institute. Click here to donate: http://www.crab.org/Donate.aspx


CRAB Presented at 2015 Life Science Innovation Northwest

SEATTLE, June 17, 2015 – Tammy Buist, VP and Chief Business Development Officer, represented Cancer Research And Biostatistics (CRAB) and gave a podium presentation at the Life Science Innovation Northwest exposition (LSINW). The event was hosted by the Washington Biotechnology & Biomedical Association (WBBA). Ms. Bust described CRAB's impact on cancer using innovative partnerships and alliances, including the Pacific Rim Cancer Biostatistics Conference that CRAB will host in August and Lung and Pancreatic Cancer clinical trials run through CRAB's clinical trials consortia.

Ms. Bust's presentation was on June 30, 2015, at 2:10 PM in the Innovation section of the conference.


Berg President Interview on A.I. in Healthcare and 'Project Survival'

BOSTON, June 11, 2015 – Berg President and CTO Niven Narain gave an interview with Fox Business News on Project Survival and the use of artificial intelligence and big data in their work with pancreatic cancer. Watch the full interview on YouTube.


2014 Annual Report Published

Click the image above to view or download the report. 

 


CRAB Founder Speaks at the SCT Annual Meeting and a Memorial to Marvin Zelen

John Crowley, PhD and Chief of Strategic Alliances at Cancer Research And Biostatistics (CRAB), will participate in a session at the Society for Clinical Trials (SCT) Annual Meeting on May 18, 2015. The session, titled "Recipe to becoming a successful biostatistician in a collaborative environment", will focus on successful career development and leadership. Mentoring, communication and project management strategies will be discussed by Dr. Crowley and a panel of three other speakers.

Dr. Crowley will also give an invited talk at the SCT's memorial session for Dr. Marvin Zelen. Dr. Crowley will discuss Dr. Zelen's contributions to cancer clinical trials and his influence on Dr. Crowley's own work.

John Crowley is the Founder and until 2014 the Chief Executive Officer of CRAB, a nonprofit research organization dedicated to helping conquer cancer. He received his PhD in Biomathematics from the University of Washington, and has had faculty appointments at the University of Wisconsin, the University of Washington and the Fred Hutchinson Cancer Research Center.


Co-founder Dr. Catherine Crowley Moves on to “Other Duties”

CRAB co-founder Dr. Catherine Crowley has decided to pursue a new chapter in her life. After 16 years in leadership, Cay retired from CRAB at the end of December.

Dr. Cay Crowley joined her husband, Dr. John Crowley, in founding CRAB in 1997 as the home of the data management component of the SWOG Statistical Center, with a mission to help conquer cancer and other diseases using biostatistical principles and innovative data management methods. Cay became the original employee when CRAB’s first office opened in the Crowley’s basement in 1999. Sixteen years later, CRAB is a well-known research organization with more than 80 employees.

Over the years, Cay has served several administrative roles at CRAB. Having a doctorate in Developmental Psychology from the University of Washington served Cay well in taking on the many challenges that are a part of building an effective organization. After completing postdoctoral training in clinical psychology at University of Wisconsin, Cay practiced in Wisconsin before moving to Seattle where she co-founded Northwest Psychological Services. Cay says that her training and business experience provided her with many of the skills she has used at CRAB.

Serving over the years as Chief Administrative Officer, Chief Operations Officer, and Chief Financial Officer, Cay performed the usual tasks associated with the titles and many others that fall under “other duties, as assigned,” always included in her job descriptions. Cay led the development of sound administrative, financial, and human resources policies and procedures. Regulations don’t always make it easy to produce policies that are consistent with making CRAB a great place to work, but Cay worked diligently to strike a balance. Recently, Cay completed comprehensive revisions to our policies and procedures, and was instrumental in the design of the SharePoint site where the documents are now stored.

For many years, Cay was responsible for the development and maintenance of CRAB's strategic plan. As a corporate officer, Cay served as a CRAB Vice President, with Board-defined roles as Secretary and Treasurer, and she spent many years as the primary liaison with the Board of Directors. Cay was also CRAB’s chief Annual Report and newsletter writer.

Cay’s financial stewardship has been demonstrated in the development of an excellent Finance team who follow sound policies and procedures that have consistently resulted in clean audits and accurate budgeting, and in the development of a reserve fund and the creation of a rich benefit package for employees.

Included among Cay’s roles is the acquisition of office space, facilities, and equipment to meet the technology needs associated with biostatistical analyses. In 2007, Cay led an effort to obtain support for a high dimensional genomic and proteomic data to support cancer biology research and clinical trials. Support to purchase the system of servers and disk storage came from the Myeloma Institute for Research and Therapy (MIRT), MJ Murdock Charitable Trust, and the Seattle Foundation.

CRAB has grown over the years and Cay has overseen moves from the Crowley basement to the Metropolitan Park West building in downtown Seattle and across the street to the Metropolitan Park East building. In 2009, Cay completed negotiations on an affordable 10-year lease. In 2010, Cay had oversight of a remodel of the two floors that CRAB occupies, including all new network cabling, functional meeting spaces, and a modern computer data center with a cooling system independent of the building’s system, a new power supply with battery backup, and a sprinkler system that is charged with water only in the event of a fire. The new lease ensures that CRAB remains at Met Park East into April, 2020.

Throughout her career Cay has been the consummate team player, providing support for many collaborative efforts to implement John Crowley’s vision to form CRAB into a leading cancer research center. Cay’s financial management, administrative oversight, and organizational efforts supported the work of many at CRAB in the accomplishment of important projects.

Chief Executive Officer Dr. John Crowley, making his own transition in 2015 to Chief of Strategic Alliances, said, “Cay’s many contributions have been vital to CRAB’s growth as an effective research organization. I wouldn’t have started CRAB if I wasn’t sure that I could trust Cay to do whatever was required for us to succeed as an organization.”

As CRAB’s co-founder, Cay will continue to contribute through her legacy and support. Supplied with a permanent key card to CRAB offices, she will continue to be sought out for advice when she’s in the building. Cay’s next job description isn’t written yet, but it’s sure to include new challenges and adventures and the quintessential other duties, as assigned, with one important distinction. For her new job description, Cay said, “I’ll be the one assigning the other duties.”


​CRAB Scientists Presented at Clinical Trials Training Course

Antje Hoering and John Crowley presented at a training workshop in integrative oncology research hosted by Cancer Treatment Centers of America CTCA at the Western Regional Medical Center in Phoenix, AZ on Friday and Saturday, April 24-25, 2015. Drs. Hoering and Crowley gave talks on Phase I and II clinical trials and help with protocol development and related statistical considerations.

CRAB has collaborated with CTCA since 2013 on training workshops. John and Antje are proud to continue this work with CTCA.


CRAB Networks with Survivors

March 31, 2015 -- CRAB continues to engage with the local community of cancer survivors and patient allies. CRAB was honored to host presentations on cancer survivorship and patient advocacy, given by Anna Gottlieb, Director of Gilda's Club Seattle and two survivors: Ann Collier, RN and her daughter Katie Collier, a University of Washington Junior and Huskies Women's Basketball player. Ann and Katie shared her story of surviving breast cancer and Katie is a survivor of leukemia. The event, attended by CRAB employees and Board of Directors members, featured information on CRAB's plans to create a survivorship website in collaboration with SWOG.

Lunch, smiles and a few tears were shared. Larry Kaye (Data Coordinator) called Ann and Katie "extraordinary cancer survivors, truly inspirational...[their story] makes me proud to work in non-profit cancer research". Pingping Qu (Senior Biostatistician) said "it was a great session...I admit I had to use some kleenex myself". Grace Powell (Regulatory Affairs/QA Manager) called the event "another reminder of why we do what we do!"


Help Us Win The Game Against Cancer

Today, CRAB is participating in the Seattle Foundation’s GiveBig – Day of Champions.

What is GiveBig?

The Seattle Foundation’s GiveBIG is a one-day, online charitable giving event to inspire people to give generously to nonprofit organizations, such as CRAB, to make our region a healthier and more vital place to live.

Join CRAB’s Circle of Champions today!

Why Not Make a Direct Donation to CRAB instead?    

Your direct contributions to CRAB are always welcome and greatly appreciated!

On May 5th, - From midnight to midnight - we’re asking our friends and supporters to make a donation to CRAB via the Seattle Foundation’s website.  Every donation to CRAB will receive a prorated portion of the matching funds (or “stretch”) pool. The amount of the “stretch” depends on the size of the total stretch pool and how much is raised in total donations on GiveBIG day. 

Doesn’t matter if you give a dollar or $1,000

Every contribution makes you a CRAB M.V.P.

Help us win the game against cancer – join our Circle of Champions on May 5!

To find out how your tax-deductible donations to CRAB impact cancer research and cancer treatment outcomes, please visit CRAB.org or email us at

To learn more about GiveBig and the Seattle Foundation, visit http://www.seattlefoundation.org/.


CRAB at the SWOG Group Meeting This Week

CRAB colleagues will attend and participate in the Spring 2015 SWOG Group Meeting in San Francisco this week, April 29 through May 2. CRAB staff will facilitate the Clinical Trials Training Course for new CRAs, answering questions and sharing expertise in clinical trial data management.

CRAB will also facilitate presentations and activities for the SWOG prevention study PACES (SWOG study S0820 - Preventing Adenoma of the Colon with Eflornithine & Sulindac) on April 30th. There are over 300 SWOG institutions and 200+ non-SWOG institution’s participating in the study.

SWOG’s Social Media Working Group will bring the founder of TheMedNet and the Executive Director of The Survivor Games to networking events at the Group Meeting, highlighting efforts to connect cancer survivors with each other. Plenary session topics will include proteomics and efforts to “go global” with SWOG trials.


CANCER - The Emperor of All Maladies​

Based on the 2010 Pulitzer Prize-winning book by Siddhartha Mukherjee, this three-part, six-hour documentary is one you will not want to miss.

http://kcts9.org/programs/cancer-emperor-of-all-maladies/about


CRAB at Seattle's Big Climb 2015

CRABCares, the community outreach arm of CRAB, supported lymphoma and leukemia research on Sunday, March 22, 2015 by joining cancer survivors, families and friends in the Big Climb. The team CRABBY CLIMBERS scaled the 69 flights of stairs with the larger community of survivors, family and friends. Several CRAB climbers finished in less than 14 minutes!

This event marked CRAB's third appearance at the inspirational event. If you marched in the event we hope you had fun! Watch this space for more of future CRABCares events.




CRAB Scientist Spoke At Biotech Forum on Collaboration

John Crowley, PhD and Chief of Strategic Alliances at Cancer Research And Biostatistics (CRAB), spoke at a forum hosted by the MIT Enterprise Forum on Wednesday, February 25, 2015. The forum, titled How Alliances Are Saving Lives, included Dr. Crowley in a panel discussion on how biotech collaborations enhance disease treatments in a rapidly-changing healthcare landscape. CRAB Vice President and CBDO Tammy Buist remarked that with "a meaningful set of presentations and the keynote, Dr. John Crowley really brought [the discussion] to life with his extensive collaboration and alliance experience.”

John Crowley is the Founder and until 2014 the Chief Executive Officer of CRAB, a nonprofit research organization dedicated to helping conquer cancer. He received his PhD in Biomathematics from the University of Washington, and has had faculty appointments at the University of Wisconsin, the University of Washington and the Fred Hutchinson Cancer Research Center.

The forum was held at the Washington State Convention Center from 5:30 to 8:30 PM. For more information about the event please read the flyer (PDF) and visit the MIT Enterprise Forum website at http://www.mitwa.org/events/innovation-forum/biotech-collaborations.


CRAB Vice President Delivered Keynote at Oregon Healthcare Technology Conference

Tammy Buist, Vice President and Chief Business Development Officer of Cancer Research And Biostatistics (CRAB) delivered the keynote address entitled “Swamped with Information: Harnessing Data for Healthcare” at the Technology Association of Oregon conference on Friday, February 6, 2015.

The conference, titled “Reinventing Healthcare: How New Technologies are Transforming Healthcare Delivery” explored how advances in technology will transform healthcare over the next 10 years. The half-day event featured panels and moderated discussions on topics in healthcare: inevitable changes driven by aging populations, pent-up consumer demand, cost pressures and the intersection of technological advances with these issues. CRAB Board of Directors member Frank X. Curci served as a panel-discussion moderator.

CRAB is a nonprofit research organization dedicated to helping conquer cancer through the application of biostatistical principles and innovative data management methods. Tammy Buist received her BA in Biochemistry from Whitman College and her MBA from the MIT Sloan School of Management.

Location: Multnomah Athletic Club, 1849 SW Salmon St., Portland, 97205
Date: Friday, February 6, 2015
Time: 7:30 AM to 12:00 PM

Video of event on YouTube: http://youtu.be/KBAnCSsx_Tw

For more information about the event please visit the website at http://www.techoregon.org/event?eventid=12643415797 or see the event flyer below:


CRAB at Seattle's Big Climb 2015

CRABCares, the community outreach arm of CRAB, will support lymphoma and leukemia research on Sunday, March 22, 2015 by joining cancer survivors, families and friends in the Big Climb. This event will mark CRAB's third appearance at this inspirational event. If you're marching in the event we hope to see you there.

For more information about the Big Climb please visit the website:

http://www.llswa.org/site/PageServer?pagename=bc_home


Shop at Fred Meyer and raise money for CRAB

Through its Community Rewards program, Fred Meyer is giving away $625,000 to nonprofits each quarter in 2014.

Enroll online and link your Rewards Card to CRAB by visiting www.fredmeyer.com/communityrewards. Don't worry; you'll still receive all Rewards Card perks. You'll just also raise money for CRAB every time you shop and use your Rewards Card!

So be sure to link your rewards card to CRAB, and the next time you shop at Fred Meyer, know you are helping support cancer research.


PurpleStride 2014: Pasta and Participation

Members of CRABCares, CRAB colleagues and their familes joined together over the past week, at CRAB and at Magnusson Park in Seattle's Sand Point neighborhood, to support CRABCares' participation in PurpleStride 2014. Much support and merriment was shared to benefit pancreatic cancer research. ​

The CRABCares pasta potluck on October 30th featured the cooking talents of CRAB employees who dazzled diners with baked ziti, spaghetti and quinoa noodles, among other dishes. Raffle prizes were won and smiles were spotted. On November 2nd colleagues gathered under CRAB's canopy at PurpleStride 2014 to share cocoa, doughnuts, run/walk strategies and cheers.


CRAB Presents at CANSSI in Toronto

Dr. Antje Hoering presented at the Workshop on Statistical Issues in Biomarker and Drug Co-development. The workshop was held in Toronto and sponsored by CANSSI, the Canadian Statistical Sciences Institute.

The 1.5-day workshop on biomarker and drug co-development focused on education of researchers about emerging developments in statistical designs and analyses for clinical trials and translational research, as well as to identify open statistical problems for which attendees will consider organizing research proposals. International experts provided an introduction to biomarker data and an overview of current design, analysis, and reporting principles with issues for research. Workshop participants solidified their knowledge about the current state of the field(s); networked, identified knowledge gaps and to proposed research initiatives that will be the focus of a full grant application which will globally enhance and expedite biomarker research.

For more details about the workshop please visit its website at http://www.fields.utoronto.ca/programs/scientific/14-15/biomarker/.


Thank You Government Employees

Cancer Research And Biostatistics (CRAB) would like to thank all of the employees of King County government and the federal and military personnel who support our work through employee giving programs in 2014.

CRAB is focused on people, people you may know – people with underfunded and under-researched cancers, the ones we can’t yet routinely cure, such as myeloma, pancreatic and lung cancers.

Today, these three cancers alone take more than 209,000 lives a year in the United States.

Thank you for helping us reduce these numbers!

In the last year along, CRAB helped bring new choices to patients – one of these could be the one that makes a difference.

With your generous contributions, we can build upon these successes to provide more treatment options to event more cancer patients, sooner.

Thank you for your support and we look forward to partnering with you again in 2015!


  

CRAB Joins the #GivingTuesday Movement 

We had a day to give thanks and two days for getting great deals.

Now, we have a a day dedicated to giving back and supporting our favorite charities - #GivingTuesday, a day of online giving.

Cancer Research And Biostatistics (CRAB) is proud to join this growing movement of generosity on December 2.

CRAB is focused on people, people you may know - people with underfunded and under-researched cancers, the ones we can’t yet routinely cure, such as myeloma, pancreatic and lung cancers. Today, these three cancers alone take more than 209,000 lives a year in the U.S.

We need to reduce these numbers – you can help. 

In the last year alone, CRAB helped bring new choices to patients– one of these could be the one that makes a difference.    With your contributions, we can build upon these successes to provide more treatment options to even more cancer patients, sooner.

                                                              

Thank you for Supporting CRAB on #GivingTuesday! 


Pancreatic Cancer Research at CRAB Receives Support from Northwest Artist

Lampwork bead artist, Valerie Coxon, RN, PhD, owner of AnnieAlta, will donate the sale of three necklaces to support pancreatic cancer research at CRAB when she participates in Purple Friday Weekend, a fine arts and craft show. The event will be held Nov. 28 to 30 (Noon to 6 pm) at the Ryan James Fine Arts gallery located at 11905 124th Ave NE in Kirkland. Her gift to CRAB is inspired to help pancreatic cancer research and to honor the recent passing of a friend of the Ryan James gallery, Stephen Hal Mohlman, following his battle with pancreatic cancer.

Please read the full story about NW Artist’s Purple Donation.

 


CRAB Teaching Abroad

​Drs. Antje Hoering and John Crowley taught at the "Statistics in Clinical Oncology" workshop in Brussels on October 9-10, 2014.

The purpose of the workshop was to discuss fundamental concepts of oncology clinical trials and to provide real-world examples of such trials using CRAB's online tools and calculators. Drs. Hoering and Crowley were invited as instructors for the workshop as renowned statisticians and data scientists.

The conference was attended by twelve participants with medical backgrounds from various drug companies. Dr. Hoering was happy to note that "everyone was very interested, asked many questions and we had lively discussions. We taught how to use the tools on our [Resources] web page. They loved those and said they would show their colleagues. It was great for creating buzz for CRAB."



















CRAB Scientists Teach Brussels Statistics Workshop

Drs. John Crowley and Antje Hoering will teach the "Statistics in Clinical Oncology" workshop in Brussels, October 9-10, 2014. The event will feature two day-long modules that cover the following topics:

Module 1: Phase I and II Oncology Clinical Trials

Topics in early phases of oncology clinical trials (phase I-II) will be covered. Real world examples of recent SWOG and CRAB clinical trials will be given and trial designs will be demonstrated using CRAB's on-line calculators. The first half of the course will review basic concepts of oncology clinical trials including safety, efficacy and endpoint considerations. The most common phase I trial designs will be discussed. Single stage, two-stage phase II trial designs and randomized phase II trial designs, as well as pros and cons of these designs in various clinical settings, will be covered. The third edition of the Handbook of Statistics in Clinical Oncology edited by the instructors was published in the summer of 2012. The second half of the course will cover current topics in phase II oncology clinical trial designs based on this Handbook, including trial designs for cytostatic or targeted agents. Variations with targeted agents include dose exploration in seamless phase I/II trials; multiple strata phase II trials.

Module 2: Phase III Oncology Clinical Trials

Topics in phase III oncology clinical trials will be covered. Superiority and non-inferiority oncology phase III trials as well as DSMC issues will be reviewed. Real world examples of recent SWOG and CRAB clinical trials will be given and trial designs will be demonstrated using CRAB's on-line calculators. The third edition of the Handbook of Statistics in Clinical Oncology, edited by Drs. Crowley and Hoering, was published in the summer of 2012. The second half of the course will cover current topics in phase III oncology clinical trial designs based on this Handbook, including trial designs for cytostatic or targeted agents. Variations with targeted agents include phase II/III trials; and phase III designs for joint biomarker and drug development.

For more details about the event please visit the website:

http://hygeiaprojects.be/statistics-in-clinical-oncology.html

 


CRAB Hosts Young Investigators Conference

The annual SWOG Young Investigators conference was hosted by CRAB September 29th through ​October 1st. The conference featured SWOG leadership members, CRAB data managers and six investigators who were introduced to the ways and means of SWOG protocol development, maintenance and administration.

For more details about the event please visit the SWOG website: 

https://swog.org/Visitors/InvestigatorsTraining.asp

 

Art Institute of Seattle Helping CRAB

The CRAB 2013 Annual Report was designed and produced by the talented design team of Moe Abbott and Minhye Kim – student graphic designers from the Art Institute of Seattle. Selected from eight competing students, the winning design concept uniquely showcases CRAB’s impact and progress in the areas of lung and pancreatic cancers and myeloma and leukemia research.

Please select this link to be directed to the 2013 Annual Report. To print a copy, please download the PDF version.     

We hope you enjoy reading CRAB’s 2013 Annual Report and learning more about our groundbreaking work.




Lead CRAB Scientist Spoke at IBC Conference

CRAB CSO Antje Hoering, PhD., served as the Chair and Organizer of an invited session at the 27th International Biometric Conference (IBC) in Florence, Italy. The session took place on Monday, 7 July, 2014.

The title of Dr. Hoering's session was Biomarkers in Oncology Clinical Trials. Speakers in the session included Michael LeBlanc, Ph.D. of the Fred Hutchinson Cancer Research Center; Shigeyuki Matsui of the Institute of Statistical Mathematics, Tokyo and Donna Ankerst, Ph.D.of the Technische Universitaet Muenchen, Germany. John Crowley, Ph.D. from CRAB served as the discussant. Session topics included the direction of subgroup modeling in Phase III clinical trial designs, maintenance of clinical risk calculators and statistical analysis plans in Phase III trials.

For more information about the 2014 IBC Conference please visit the event website at http://www.ibs-italy.info/ibc-2014.html.


GiveBIG 2014: Thank You!

With your help, we raised over $6,600 in support of the impactful work we're doing at CRAB.

Your contributions will help us advance the standard of care and improve treatment for cancer patients. Thank you again for supporting our mission and standing with us in our belief that "Every Cancer Patient Counts".

Missed GiveBIG Day 2014? Not a problem! CRAB accepts donations year-round. Check out our donation page at Donate to CRAB for more information and a secure online donation link.


Lead CRAB Scientist Spoke at AACR Annual Meeting

CRAB CSO Antje Hoering, PhD., gave an invited talk at one of the major methods workshops of the Annual Meeting of the American Association for Cancer Research (AACR) on April 5, 2014.

Nearly 18,000 researchers, patient advocates and other professionals in the field of cancer from around the world attended the AACR annual meeting. Dr. Hoering's talk was titled "Statistical Designs of Complex Phase II Trials and Definitive Phase III Studies in the Era of Targeted agents" and was part of the workshop: "Insights in the Era of Personalized Cancer Therapy and Targeted Therapies: Definitive Advanced Stage Clinical Trials." For more information about the event please visit the AACR website at http://www.aacr.org/.


CRAB Collaborates with the International Biometric Society

CRAB's Chief Scientific Officer Antje Hoering, Ph.D., has been elected as a representative from the Western North American Region of the International Biometric Society: http://www.biometricsociety.org/. The IBS promotes the development and application of statistical and mathematical theory and methods in the biosciences, including biomedical science and public health, agriculture, ecology, environmental sciences, forestry, and allied disciplines. Dr. Hoering will represent the organization to the international governing body of the IBS.


CRAB to Present at Clinical Trials Conference

CRAB will give an oral presentation at the Annual Meeting of the Society For Clinical Trials (SCT) in May of 2014. The presentation is titled “Mixed Mode Follow-up for an Aging Study Population” and will focus on participants of the SELECT clinical trial. For more information on SCT visit their website. Information on SELECT may be found via the National Cancer Institute.


Give Big to CRAB & Grow your Gift! Donate today to make a BIG impact!

 

Today is the Seattle Foundation's GiveBIG event. GiveBIG is a unique, one-day, online charitable giving event that supports local charities, including CRAB. In addition to the donations CRAB receives, GiveBIG contributions will also be partially matched by a "stretch pool" provided by the Seattle Foundation and GiveBIG sponsors. The more donations CRAB receives, the more we will get from the stretch pool!

Your contributions will help us continue to advance the standard of care for cancer patients and help improve treatment for many cancer types.

Thank you for your contribution!

Participation is fast and easy! Here's how:

  • All you need is an internet connection (or access to the internet on your mobile phone).
  • Simply visit CRAB's profile/donation page - GiveBIG = GiveCRAB

Thank you for supporting CRAB!


GiveBIG GiveCRAB

 

CRAB is poised to participate in the fourth annual online giving event on May 6th. 

GiveBIG is the Seattle Foundation's one-day online charitable giving event to inspire people in the community to give generously to non-profit organizations, like CRAB, that make our region a stronger community for all.

From 12:00 a.m. to 12:00 a.m. on May 6th, every donation made to CRAB through the Seattle Foundation's website will receive a pro-rated portion of the matching funds (or "stretch") pool - thanks to the Seattle Foundation and the GiveBIG sponsors.

The amount of the "stretch" depends on the size of the stretch pool and  how much is raised in total donations on GiveBIG day (we will "stretch" all donations up to $5,000 per donor, per organization.)

Participation is fast and easy!

  • All you need is an internet connection (or access to the internet on your mobile phone).
  • Simply visit CRAB's profile/donation page - GiveBIG = GiveCRAB

Thank you for supporting CRAB!


Strength for CRAB Partnerships 

CRAB is proud to have worked in partnership with SWOG and to have received a high score for SWOG's participation in the new National Clinical Trials Network (NCTN) program starting in March of 2014. The SWOG Statistical and Data Management Center (SDMC) is co-located at CRAB and Fred Hutchinson Cancer Research Center.


CRAB's John Crowley and Antje Hoering taught at UW Summer Institute in Biostatistics 

Drs. John Crowley and Antje Hoering conducted a workshop on the Design of Clinical Trials in Oncology at the 2nd Summer Institute in Biostatistics (SIB 2013), August 12 to 16, in the South Campus Center of the University of Washington in Seattle.

This Institute was a series of two-and-a-half day workshops conducted by experts in the field and was designed to introduce participants to modern issues in the design and conduct of clinical trials and the statistical analysis of clinical trial data. Drs. Crowley and Hoering covered all phases of oncology clinical trials (Phase I-III).

Details about the event are available in this PDF:download


John Crowley Awarded the 2013 Breslow Lecture 

John Crowley, PhD, President and CEO of CRAB, was awarded the distinguished 2013 Norman E. Breslow Lectureship from the University of Washington’s School of Public Health. Dr. Crowley will give a presentation for the School titled "A Brief History of Survival Analysis". The event will run from 3:30 to 5:00pm on Thursday, June 13th, 2013 in Room T-733 of the UW Health Sciences building.

The Norman E. Breslow Distinguished Lectureship was established in 2006 to honor the instrumental scientific contributions of Norman E. Breslow in the Department of Biostatistics of the School of Public Health and Community Medicine. The Lectureship is awarded annually to an individual who has made important contributions to the advancement of biostatistical methodology and its applications in the health sciences. Former Breslow Lecturers include Mitchell H. Gail of the National Cancer Institute and David Clayton of Cambridge University.

Details about the event are available in this PDF: download 

For more information, contact Sandra Coke at the School of Public Health: 206-685-9496,  .


CRABCares at the Free to Breathe Run/Walk

 

On September 7th, 2013 CRAB employees participated in the Free to Breathe 5K Run/Walk & 1-Mile Walk event. The event featured 404 participants who raised over $55,000 to support lung cancer research.

The CRABCares mission is aligned with the goal of such events: to support community efforts in the fight to prevent and cure cancer.


CRAB Presenting at Cancer Prevention Conference

CRAB will give a poster presentation at the American Society of Preventative Oncology (ASPO) in March 2014. The presentation is titled “Retention of Minority Populations in the Selenium and Vitamin E Cancer Prevention Trial” and will focus on participants of the SELECT clinical trial. For more information on ASPO visit their website. Information on SELECT may be found via the National Cancer Institute.


Partnership in Cancer Trials Brings Hope for Patients

Cancer Research And Biostatistics (CRAB) recently announced enrollment of the first patient into the inaugural clinical trial sponsored by its Clinical Trials Consortium (CTC). The CRAB CTC mission is to ensure rapid clinical testing of new and innovative cancer treatments, and is focusing on lung cancer as its first target. By engaging front-line treating oncologists to push the boundaries of patient care, the aim is to improve the standard of care and extend overall survival. The trial is being funded by Onyx Pharmaceuticals, Inc., an Amgen subsidiary.

For complete details access the full press release PDF document at this link. download


You Shop and Amazon Donates to CRAB

In November 2013, Amazon.com launched a charitable program called AmazonSmile. This program is designed to give 0.5% of the price of every eligible purchase made to the charity of your choice. CRAB is participating in the program and is listed on the Amazon Smile site as “Cancer Research And Biostatistics”. Almost every product sold by Amazon is eligible and there is no cap on the amount Amazon will donate. Thank you for considering this option when making your online purchasing decisions!

Cancer Research And Biostatistics

 


CRAB Collaborates with Local Giving Campaigns

CRAB recently participated in two local fundraising campaigns: the King County Chapter of the Combined Federal Campaign (CFC) and the King County Government’s Employee Giving Program Expo (KCEGP). CRAB was proud to participate in these events.

The CFC creates opportunities for federal civilian, postal, and military employees to donate to local, national, and international non-profit organizations. CRAB joined other participating organizations to publicly thank the military and federal employees for their participation in the Combined Federal Campaign’s employee giving program.

The KCEGP showcases King County’s Employee Giving Program, a philanthropy resource for County employees. The Program includes an Annual Giving Drive in which County employees may make donations to hundreds of local non-profit organizations. 


For Immediate Release - Launch of Project Survival℠: Collaboration Aims to Uncover First Ever Biomarker for Pancreatic Cancer

Berg, BIDMC Cancer Center, CRAB/Pancreatic Cancer Research Team work together to eradicate disease

BOSTON, April 7, 2015 – The search to discover and validate the first-ever clinical biomarker to diagnose and treat pancreatic cancer is at the foundation of a new, cross-sector collaboration. Berg, a biopharmaceutical company committed to uncovering health solutions through a data-driven, biological research approach; the Cancer Center at Beth Israel Deaconess Medical Center (BIDMC), a Harvard Medical School teaching hospital, and the Pancreatic Cancer Research Team (PCRT) managed by Cancer Research And Biostatistics (CRAB) announced today they will work together to eradicate the disease.

According to The National Cancer Institute, nearly 47,000 Americans were diagnosed with pancreatic cancer in 2014, a disease from which only 6.7 percent will survive five years. "Pancreatic cancer will become the No. 2 cause of cancer death in the United States within five years, surpassing both breast and colon cancer," said James Moser, MD, director of the research team for BIDMC's new Pancreas and Liver Institute and an Associate Professor of Surgery at Harvard Medical School.

"Finding a new biomarker will bring real hope to patients with pancreatic cancer. Currently, 70 percent of people with even the smallest pancreatic tumors pass up potentially life-saving treatments. We believe that our new collaboration with Berg and the Pancreatic Cancer Research Team represents the dawn of the kind of precision medicine needed to beat this terrible disease."

You may access the full press release via this PDF.


CRAB Appoints Dr. Antje Hoering as New CEO

 

Seattle, WA. November 3rd, 2014. Cancer Research And Biostatistics (CRAB) announced today that its Board of Directors named Dr. Antje Hoering as the organization’s next Chief Executive Officer, effective January 1, 2015. Dr. Hoering brings distinguished academic and scientific achievements, executive leadership and over 15 years of experience to the role. Dr. Hoering, currently the Chief Scientific Officer at CRAB, presently serves as the lead statistician for the SWOG Myeloma Committee and is an active member of the Myeloma Steering Committee for the National Clinical Trials Network. Dr. Hoering also serves as the Director of the Biostatistics Core for a SPORE grant funded through the Sarcoma Alliance for Research Through Collaboration, and is the Co-Director of the Biostatistics Core for a Program Project through the Myeloma Institute for Research and Therapy.​

Dr. John Crowley, CRAB’s current CEO says “Antje brings a unique and comprehensive background in applied and methodological research in biostatistics, encompassing areas such as the design and analysis of oncology clinical trials, as well as the analysis of a wide variety of correlative data. I have worked with Antje for 10 years at CRAB, and am proud to hand over the leadership reins to her.”

Dr. Antje Hoering comments, “I am honored and humbled to be taking over the reins from our founder, John Crowley. This is a very exciting time for oncology clinical trials and CRAB. There have been great advances in the treatment of cancer over the last few years and it is now more important than ever to definitively test the efficacy and tolerability of these treatments in soundly-designed clinical trials. CRAB offers an integrated, state-of-the-art infrastructure including sophisticated statistics, secure electronic data capture as well as experienced data management to lead such trials.”

Hoering will succeed John Crowley, CRAB’s founder and CEO since 1997, who will stay on to focus on research and project activities and will continue to serve as CRAB’s Chairman of the Board.

Dr. Hoering will be based at CRAB’s headquarters in Seattle, WA.

About Cancer Research And Biostatistics (CRAB)

CRAB is a non-profit organization whose mission is to help conquer cancer and other diseases through the application of biostatistical principles and innovative data management methods. CRAB provides a complete suite of cancer clinical trial services including the design of therapeutic and prevention trials, customized electronic data capture platforms, and data management and statistical services from clinical protocol design to final data analysis and presentation.

For more information, visit www.crab.org.

Media Contact for CRAB
Tammy Buist
Vice President, Chief Business Development Officer
206.839.1796
Email: tammyb@crab.org
www.crab.org


Responsibility for Pancreatic Cancer Research Team Moves to Seattle Non-Profit Institution

 

 

 

Seattle, WA. September 10, 2014 Seattle’s own Cancer Research And Biostatistics (CRAB), and Translational Drug Development (TD2) in Scottsdale, would like to jointly announce CRAB’s assumption of responsibility for the PCRT, a world-renowned consortium comprised of a team of pancreatic cancer experts committed to improve treatment outcomes for patients with this deadly cancer.

Founded by leaders in pancreatic cancer clinical research, the PCRT is a consortium of more than 40 clinics and leading research institutions worldwide and serves as a premiere resource for the latest clinical trials. In addition, the PCRT provides a valuable collaborator for biotech and pharmaceutical companies looking to develop new agents for patients with pancreas cancer. This network provides the world's most coordinated effort dedicated to rapidly translating research discoveries into new treatments and care.

“Dr. John Crowley and CRAB have a distinguished record in clinical trials excellence. The PCRT has been working with the CRAB team for over ten years. It is gratifying to see CRAB take this growing group of devoted investigators to the next level”, said Daniel D. Von Hoff, M.D., FACP, Physician in Chief, Distinguished Professor, Translational Genomics Research Institute (TGen), Chief Scientific Officer, Scottsdale Healthcare, and one of the Founders and current Board member of PCRT.

You may access the full press release at this link: http://www.prweb.com/releases/2014/9/prweb12163611.htm 


Appointment of CFO Represents Transition

Former long-term Battelle financial manager fills Chief Financial Officer role at leading cancer research organization

Seattle, WA, March 28, 2014 – Cancer Research And Biostatistics (CRAB) today announced the appointment of William S. Charters to the position of Chief Financial Officer. Mr. Charters will guide the fiscal direction of CRAB while it seeks to expand current and future collaborations with cancer centers, clinical research consortia, private industry, and non-profit groups involved in oncology clinical trials.

CRAB’s mission is to help conquer cancer and other diseases through the application of its expertise in biostatistical principles and innovative data management methods. Prior to joining CRAB, Mr. Charters served as financial manager implementing financial and operational initiatives in support of strategic objectives for Battelle Memorial Institute focused on improving public health and data analytics, working with government and commercial clients to accelerate innovation in health and life sciences. Mr. Charters holds an MBA from the Gonzaga University School of Business.

Mr. Charters will report to John Crowley, PhD, Chief Executive Officer, a leader in the development and application of biostatistical methods to improve oncology clinical research. “Appointing Bill to the CFO role is a reflection of our desire to position CRAB into the future,” Dr. Crowley provided in a statement. “He will provide his leadership across the organization, and further develop the impact CRAB can have on helping to conquer cancer.”

Patricia Ware
Office Manager
Office: 206 839 1734
patriciaw@crab.org
www.crab.org


2013 Marvin Zelen Leadership Award in Statistical Science Recipient: John Crowley, Ph.D.

John Crowley, Ph.D.John Crowley, PhD, President and CEO of CRAB has been chosen to receive the 2013 Marvin Zelen Leadership Award in Statistical Science. Dr. Zelen is world-renowned for development of clinical cancer trial methodologies, among other foundational advancements in biostatistics.

The award, granted by the Harvard School of Public Health in the name and spirit of Dr. Zelen, recognizes an individual in government, industry or academia who by virtue of his or her outstanding leadership has greatly impacted the theory and practice of statistical science. The most distinguishing criterion is the awardee’s contribution to the creation of an environment in which statistical science and its applications have flourished. Dr. Crowley will deliver a public lecture on statistical science at the Harvard School of Public Health on Friday, May 24 where he will be presented with a citation and an honorarium.

John is well-known for his visionary leadership in three areas in which Marvin himself set the standard: i) development of an outstanding statistical center within the National Cancer Institute (NCI) cooperative group program, ii) founding of a non-profit corporation whose mission is to “help conquer cancer … through the application of biostatistical principles …”, and iii) promotion of statistical science internationally by exporting modern clinical trials methodology to researchers in Asia and Latin America. John is also recognized for his outstanding individual contributions to methodological research in survival analysis, to substantive research on the treatment and prevention of cancer, and to the training, mentoring and inspiring of the next generation of statistical scientists. He has over 350 peer-reviewed publications and has contributed to and edited several books on survival analysis and methodology of clinical trials. Dr. Crowley received his undergraduate degree from Pomona College, Claremont, CA, and his Master of Science and PhD in Biomathematics from the University of Washington, Seattle. He is a fellow of the American Statistical Association and the American Association for the Advancement of Science. Crowley led the Biostatistics Unit at the University of Wisconsin Clinical Cancer Center, was the head of Biostatistics Program at the Fred Hutchinson Cancer Research Center, and recently completed nearly 30 years as the Group Statistician of SWOG, a national clinical trials consortium funded by the NCI. In 1997 Dr. Crowley founded and currently serves as the CEO and President of Cancer Research And Biostatistics.


Appointment of CSO Signals Commitment to Cancer-Fighting Mission

Expert in oncology statistics fills Chief Scientific Officer role at leading cancer research organization

Seattle, WA, January 10, 2013 – Cancer Research And Biostatistics (CRAB) today announced the appointment of Antje Hoering, PhD to the newly-created position of Chief Scientific Officer. Dr. Hoering will guide the scientific direction of CRAB while it seeks to expand current and future collaborations with cancer centers, clinical research consortia, private industry, and non-profit groups involved in oncology clinical trials.

CRAB’s mission is to help conquer cancer and other diseases through the application of its expertise in biostatistical principles and innovative data management methods. Dr. Hoering has led the CRAB statistical team for eight years, making significant contributions as the lead statistician of the SWOG Myeloma Committee, the SWOG Early Therapeutics Committee, and the Stand Up To Cancer Pancreatic Cancer Dream Team. Her accomplishments in the field of oncology research have contributed to significant advancements in the field, reflected in her co-editing the third edition of the Handbook of Statistics in Clinical Oncology. She has affiliate appointments at the Fred Hutchinson Cancer Research Center and at the University of Washington, Seattle.

Prior to joining CRAB, Dr. Hoering worked as a Senior Research Associate and Assistant Professor in Biostatistics at the Mayo Clinic and was a research scientist at Insightful Corporation. Dr. Hoering holds a PhD in Physics from the Max Planck Institute for Nuclear Physics.

Dr. Hoering will report to John Crowley, PhD, Chief Executive Officer, a leader in the development and application of biostatistical methods to improve oncology clinical research. “Appointing Antje to the CSO role is a reflection of the immense respect I have for her expertise and commitment to improve oncology patient outcomes,” Dr. Crowley provided in a statement. “In this expanded role, she will provide her leadership across the organization, and further develop the impact CRAB can have on helping to conquer cancer.”

About Cancer Research And Biostatistics (CRAB):

CRAB is a non-profit organization that provides a complete suite of cancer clinical trial services including the design of therapeutic and large scale prevention trials, customized electronic data capture platforms, and data management and statistical services from clinical protocol design to final data analysis and presentation.

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