Cancer Research And Biostatistics (CRAB) founder John Crowley, PhD and CRAB CEO, Antje Hoering, PhD, were invited by Taylor & Francis Group to serve as editors for the Fourth Edition of the Handbook of Statistics in Clinical Oncology. For this fourth edition, Megan Othus, PhD, from the Fred Hutch will join the editorial team. Many leaders in the field will contribute to this next edition to incorporate the many advancements in the field with a plan to publish this new edition in 2025. The third edition of this Handbook was published in 2012.